Duloxetine if a drug mainly used for depression but it is now also used for neuropathic pain and for the management of chronic pain. It can take up to 2 – 4 weeks to kick in before it helps with pain and you are advised to not take other pain medication with it.

It can only be prescribed by a Pain Consultant.  Mine asked me to give this drug a try as he feels a lot of my pain is Myofascial and nerve pain which can be helped if Duloxetine suits me. As with many of my other pain medications the list of possible side effects is so long that it could put you off even trying it. But, I am prepared to give it a go over the next month.

In order to try Duloxetine I have had to reduce my Tramadol right down to 100mg a day and my Amitriptyline to the lowest I can manage on so it should be interesting to see how I feel after I have been on it for a couple of weeks. I am starting on one 30mg tablet a day increasing it to two a day of 30mg and then in another two weeks just one a day of 60mg.

This is the first time in a number of years that I have had to alter nearly all my pain medication in order to try something different out and so I am keeping my fingers crossed that this will really help. Says she, who at the moment is lying on one side to type this as the sciatic nerve pain in back and giving me a lot of discomfort.

Oh, for a pain free life…………..



  1. This drug was meant to be my Miracle drug … but sadly it was not meant to be. Duloxetine and my liver had a falling out and well, the rest is history! I hope it helps and good luck 🙂


    1. Hi Cassie, Me to re the drug being a hopeful miracle drug for my pain but also sadly it didn’t hit any where near the spot and as I had to come off other strong drugs (Tramadol and Amatryptyline) to try it I was by far worse off taking it and had to go back to my usual meds. We can but try 🙂


      1. Yes sounds like you had the same as me there. It didn’t hit anywhere near. All it did was mess my liver up. Here’s to hoping some newer less heavy on the side effects kind of medicine is in the wings. Has to happen sooner or later right 🙂


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